After 10-Year Search, Scientists Find Second 'Short Sleep' Gene

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Jason Alvarez, After 10-Year Search, Scientists Find Second 'Short Sleep' Gene. University of California Dan Francisco, Aug 28, 2019.
https://www.ucsf.edu/news/2019/0 ... nd-short-sleep-gene
(:in a paper published Aug. 28, 2019, in the journal Neuron" after a 2009 report on discovery of a DEC2 mutation)

Note:
(a) 傅嫈惠  (1980 BS 中興大學食品科學 Department of Food Science, National Chung-Hsing University (the department has changed name to Department of Food Science and Biotechnology); 1986 PhD Ohio State University; 2018 member, National Academy of Science; husband Louis Ptáček)
(b) The two genes are identified from two families who are inheritary for short sleep.
(i) "The linkage analysis" is used which connects crossover / recombination (during meiosis) with presence and absence of short sleep. (Naturally not all members of a clan are short sleepers. When a clan is large is enough, gene location can be deduced through linkage analysi
(ii) Why these two genes causes short sleep remains unclear.
(iii) DEC2 (acronym for "differentially expressed in chondrocytes [軟骨細胞] 2") has been reclassified as BHLHE41 (which stands for "basic helix-loop-helix family member e41" where ).
(A) The term "differentially expressed in chondrocytes" describes gene expression, that it is mostly expressed in chondrocytes.
(B) basic helix-loop-helix
https://en.wikipedia.org/wiki/Basic_helix-loop-helix
Is just a structure within a protein.

Because a protein has unknown functions when discovered, a descriptive term such as DEC or BHLH is assigned.
(iv) adrenergic receptor
https://en.wikipedia.org/wiki/Adrenergic_receptor
is a receptor for norepinephrine (noradrenaline) and epinephrine (adrenaline) 腎上腺素; and actually are composed of two α receptors (α1, α2) and three β receptors (β1, β2, β3), each of which is encoded by a separate gene.