青蒿素

choi

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Artemisinin is excellent, but its days may be numbered.

(1) Lasker Honors for a Lifesaver. New York Times, Sept 13, 2011
http://www.nytimes.com/2011/09/13/health/13lasker.html
(World Health Organization recommends this combination therapy [artimisinin combination therapy, ACT] as the first-line treatment against the disease, replacing the previous standard treatment, chloroquine, which was losing effectiveness as malaria parasites developed resistance)

Note: Artemisia annua  青蒿
http://en.wikipedia.org/wiki/Artemisia_annua

(2) Unfortunately, resistance to artimisinin has developed in malaria parasites, in the Thai-Cambodia border. Resistance to chloroquine also first developed in the area, and spread widely to Africa.

(a) News release: Drug Resistance Could Set Back Malaria Control Success; US$ 22.5 million grant from Gates Foundation to contain malaria parasites resistant to artemisinin. World Health Organization (WHO), Feb 25, 2009.
http://www.who.int/mediacentre/news/releases/2009/malaria_drug_resistance_20090225/en/index.html
("Appropriate treatment with ACTs succeeds in more than 90% of cases")
(b) Artemisinin-Resistance Containment Project. WHO, undated.
http://www.who.int/malaria/diagnosis_treatment/arcp/en/index.html

(3) The site or mechanism of artemisinin is not clear.



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